Publications

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Peer-reviewed Journals

2008

  1. A. S. Shaikh, Y. J. Tang, A. Mukhopadhyay, J. D. Keasling 2007 Isotopomer Distributions in Amino Acids from a Highly Expressed Protein as a Proxy for Those from Total Protein, Analytical Chem 2008

2007

  1. A. Mukhopadhyay, A. M. Redding, M. P. Joachimiak, A. P. Arkin, S. E. Borglin, P. S. Dehal, R. Chakraborty, J. T. Geller, T. C. Hazen, Q. He, D. C. Joyner, V. J. J. Martin, J. D. Wall, Z-K. Yang, J. Zhou, and J. D. Keasling Cell wide responses to low oxygen exposure in Desulfovibrio vulgaris Hildenborough 2007
  2. Y. J. Tang, A. L. Meadows, and J. D. Keasling. 2007. “A kinetic model describing Shewanella oneidensis MR-1 growth, substrate consumption, and product secretion”. Biotechnol. Bioeng. 96:125-133.
  3. B.F. Pfleger, D. J. Pitera, J. D. Newman, V. J. J. Martin, and J. D. Keasling. 2007. “Microbial sensors for small molecules: development of a mevalonate biosensor.” Metab. Eng. 9:30-38.
  4. S. T. Withers and J. D. Keasling. 2007. “Biosynthesis and engineering of isoprenoid small molecules.” Appl. Microbiol. Biotechnol. 73:980-990.
  5. Y. J. Tang, A. L. Meadows, J. Kirby, and J. D. Keasling. 2007. “Anaerobic central metabolic pathways in Shewanella oneidensis MR-1 reinterpreted in the light of isotopic metabolite labeling.” J. Bacteriol. 189:894-901.
  6. Y. J. Tang, F. Pingitore, A. Mukhopadhyay, R. Phan, T. C. Hazen, and J. D. Keasling. 2007. “Pathway confirmation and flux analysis of central metabolic pathways in Desulfovibrio vulgaris Hildenborough using GC-MS and FT-ICR mass spectrometry. J. Bacteriol. 189:940-949.
  7. Y. J. Tang, J. S. Hwang, D. E. Wemmer, and J. D. Keasling. 2007. “The Shewanella oneidensis MR-1 fluxome under various oxygen conditions.” Appl. Environ. Microbiol. 73:718-729.
  8. S. H. Yoon, J. E. Kim, S. H. Lee, H. M. Park, M. S. Choi, J. Y. Kim, S. H. Lee, Y. C. Shin, J. D. Keasling, and S. W. Kim. 2007. “Engineering the lycopene synthetic pathway in E. coli by comparison of the carotenoid genes of Pantoea agglomerans and Pantoea ananatis.” Appl. Microbiol. Biotechnol. 74:131-139.
  9. Y. Shiba, E. M. Paradise, J. Kirby, D.-K. Ro, and J. D. Keasling. 2007. “Engineering of the pyruvate dehydrogenase bypass in Saccharomyces cerevisiae for high-level production of isoprenoids.” Metab. Eng. 9:160-168.
  10. D. J. Pitera, C. J. Paddon, J. D. Newman, and J. D. Keasling. 2007. “Balancing a heterologous mevalonate pathway for improved isoprenoid production in Escherichia coli.” Metab. Eng. 9:193-207.

2006

  1. Y. Yoshikuni, V. J. J. Martin, T. E. Ferrin, and J. D. Keasling. 2006. “Engineering cotton (+)-δ-cadinene synthase to an altered function: germacrene D-4-ol synthase.” Chem. Biol. 13:91-98.
  2. D-K. Ro, E. M. Paradise, M. Ouellet, K. J. Fisher, K. L. Newman, J. M. Ndungu, K. A. Ho, R. A. Eachus, T. S. Ham, J. Kirby, M. C. Y. Chang, S. T. Withers, Y. Shiba, R. Sarpong, and J. D. Keasling. 2006. “Production of the antimalarial drug precursor artemisinic acid in engineered yeast.” Nature 440:940-943.
  3. Y. Yoshikuni, T. E. Ferrin, and J. D. Keasling. 2006. “Designed divergent evolution of enzyme function.” Nature 440:1078-1082.
  4. S. K. Lee and J. D. Keasling. 2006. “Propionate-regulated high-yield protein production in Escherichia coli.” Biotechnol. Bioeng. 93:912-918.
  5. S. C. Espy, J. D. Keasling, J. Castillon, and K. Cornish. 2006. “Initiator-independent and initiator-dependent rubber biosynthesis in Ficus elastica.” Arch. Biochem. Biophys. 448:13-22.
  6. T. S. Ham, S. K. Lee, J. D. Keasling, and A. P. Arkin. 2006. “A tightly-regulated inducible expression system utilizing the fim inversion recombination switch.” Biotechnol. Bioeng. 94:1-4.
  7. D. Baker, G. Church, J. Collins, D. Endy, J. Jacobson, J. Keasling, P. Modrich, C. Smolke, and R. Weiss. 2006. “Engineering life: building a FAB for biology.” Scientific American June:44-51.
  8. A. Mukhopadhyay, Z. He, E. J. Alm, A. P. Arkin, E. E. Baidoo, S. C. Borglin, W. Chen, T. C. Hazen, Qiang He, H.-Y. Holman, K. Huang, R. Huang, D. C. Joyner, N. Katz, M. Keller, P. Oeller, A. Redding, J. Sun, J. Wall, J. Wei, Z. Yang , H.-C. Yen, J. Zhou, and J. D. Keasling. 2006. “Salt stress in Desulfovibrio vulgaris Hildenborough: An integrated genomics approach.” J. Bacteriol. 188:4068-4078.
  9. A. M. Redding, A. Mukhopadhyay, D. Joyner, T. C. Hazen, and J. D. Keasling. 2006. “Study of nitrate stress in Desulfovibrio vulgaris Hildenborough using iTRAQ proteomics.” Brief. Funct. Genom. Proteom. 5:133-43.
  10. S. K. Lee and J. D. Keasling. 2006. “A Salmonella-based propionate-inducible expression system for Salmonella enterica.” Gene 37:6-11.
  11. B. M. T. da Costa, J. D. Keasling, C. M. McMahon, and K. Cornish. 2006. “Magnesium regulation of in vitro rubber biosynthesis by Parthenium argentatum Gray.” Phytochemistry 67:1621-1628.
  12. S. H. Yoon, Y. M. Lee, J. E. Kim, S. H. Lee, J. H. Lee, J. Y. Kim, K. H. Jung, Y. C. Shin, J. D. Keasling, and S. W. Kim. 2006. “Enhanced lycopene production in Escherichia coli engineered to synthesize isopentenyl diphosphate and dimethylallyl diphosphate from mevalonate.” Biotechnol. Bioeng. 94:1025-1032.
  13. B. F. Pfleger, D. J. Pitera, C. D. Smolke, and J. D. Keasling. 2006. “Combinatorial engineering of intergenic regions in operons tunes expression of multiple genes.” Nat. Biotechnol. 24:1027-1032.
  14. Y. J. Tang, D. Laidlaw, K. Gani, and J. D. Keasling. 2006. “Evaluation of the effects of various culture conditions on Cr(VI) reduction by Shewanella oneidensis MR-1 in a novel high-throughput mini-bioreactor.” Biotechnol. Bioeng. 95:176-184.
  15. H. S. Zahiri, S. H. Yoon, J. D. Keasling, S. H. Lee, K. S. Won, S. C. Yoon, and Y. C. Shin. 2006. “Coenzyme Q(10) production in recombinant Escherichia coli strains engineered with a heterologous decaprenyl diphosphate synthase gene and foreign mevalonate pathway.” Metab. Eng. 8:406-416.
  16. J. D. Newman, J. Marshal, M. Chang, F. Nowroozi, E. Paradise, D. Pitera, K. L. Newman, and J. D. Keasling. 2006. “High-level production of amorpha-4,11-diene in a two-phase partitioning bioreactor of metabolically engineering Escherichia coli.” Biotechnol. Bioeng. 95:684-691.
  17. M. Mattozzi, S. Tehara, and J. D. Keasling. 2006. “Mineralization of paraoxon and use as a sole C and P source by a rationally designed catabolism in Pseudomonas putida.” Appl. Environ. Microbiol. 72:6699-6706.
  18. S. K. Lee and J. D. Keasling. 2006. “Effect of glucose or glycerol as the sole carbon source on gene expression from the Salmonella prpBCDE promoter in Escherichia coli.” Biotechnol. Prog. 22:1547-1551.
  19. M. C. Y. Chang and J. D. Keasling. 2006. “Production of isoprenoid pharmaceuticals by engineered microbes.” Nat. Chem. Biol. 2:674-681.
  20. D. Lubertozzi and J. D. Keasling. 2006. “Marker and promoter effects on heterologous expression in Aspergillus nidulans.” Appl. Microbiol. Biotechnol. 72:1014-1023.

2005

  1. B. M. T. da Costa, J. D. Keasling, and K. Cornish. 2005. “Regulation of rubber biosynthetic rate and molecular weight in Hevea brasiliensis by metal cofactor.” Biomacromolecules 6:279-289.
  2. S. Cooper and J. D. Keasling. 2005. “Experimental and theoretical considerations of P1-plasmid replication and segregation during the E. coli cell cycle.” J. Biol. Sci. 5:222-229.
  3. S. K. Lee, J. D. Newman, and J. D. Keasling. 2005. “Catabolite repression of the propionate catabolic genes in Escherichia coli and Salmonella enterica: Evidence for involvement of the cyclic AMP receptor protein.” J. Bacteriol. 187:2793-2800.
  4. K. Wang, J. D. Keasling, and S. J. Muller. 2005. “Effects of the sequence and size of non-polar residues on self-assembly of amphiphilic peptides. Int. J. Biol. Macromol. 36:232-240.
  5. M. J. Kang, Y. M. Lee, S. H. Yoon, J. H. Kim, S. W. Ock, K. H. Jung, Y. C. Shin, J. D. Keasling, and S. W. Kim. 2005. “Identification of genes affecting lycopene accumulation in Escherichia coli using a shot-gun method.” Biotechnol. Bioeng. 91:636-642.
  6. B. F. Pfleger, N. J. Fawzi, and J. D. Keasling. 2005. “Optimization of DsRed production in Escherichia coli: Effect of ribosome binding site sequestration on translation.” Biotechnol. Bioeng. 92:553-558.
  7. S. K. Lee and J. D. Keasling. 2005. “A propionate-inducible expression system for enteric bacteria.” Appl. Environ. Microbiol. 71:6856-6862.

2004

  1. M. M. Maharbiz, W. J. Holtz, R. T. Howe, and J. D. Keasling. 2004. “Microbioreactor arrays with parametric control for high-throughput experimentation.” Biotechnol. Bioeng. 86:485-90.
  2. E. S. Gilbert and J. D. Keasling. 2004. “Bench Scale Flow Cell for Nondestructive Imaging of Biofilms”. Meth. Microbiol. 16:109-118.
  3. K. K. Reiling, Y. Yoshikuni, V. J. J. Martin, J. Newman, J. Bohlmann, and J. D. Keasling. 2004. “Mono and diterpene production in Escherichia coli.” Biotechnol. Bioeng. 87:200-212.
  4. D. S. Reichmuth, H. W. Blanch, and J. D. Keasling. 2004. “Dibenzothiophene desulfurization pathway improvement using diagnostic GFP fusions.” Biotechnol. Bioeng. 88:94-99.
  5. N. Renninger, R. Knopp, H. Nitsche, D.S. Clark, J. D. Keasling. 2004. “Uranyl precipitation by Pseudomonas aeruginosa via controlled polyphosphate metabolism.” Appl. Environ. Microbiol. 70:7404-7412.

2003

  1. S. K. Tehara and J. D. Keasling. 2003. “Gene cloning, purification, and characterization of a phosphodiesterase from Delftia acidovorans.” Appl. Envir. Microbiol. 69:504-508.
  2. E. S. Gilbert, A. W. Walker and J. D. Keasling. 2003. “A constructed microbial consortium for biodegradation of the organophosphorus insecticide parathion.” Appl Microbiol Biotechnol. 61:77-81.
  3. N. L. Goeden-Wood, J. D. Keasling, and S. J. Muller. 2003. “Self-assembly of a designed protein polymer into b-sheet fibrils and responsive gels.” Macromolecules 36:2932-2938.
  4. R. Knopp, P. J. Panak, L. A. Wray, N. S. Renninger, J. D. Keasling, and H. Nitsche. 2003. “Laser spectroscopic studies of U(VI) with bacterial phosphate species.” Chem. Eur. J. 9:2812-2818.
  5. V. J. J. Martin, D. J. Pitera, S. T. Withers, J. D. Newman, and J. D. Keasling. 2003. “Engineering the mevalonate pathway in Escherichia coli for production of terpenoids.” Nat. Biotechnol. 21:796-802.
  6. I. Chang, E. Gilbert, N. Eliashberg, and J. D. Keasling. 2003. “A three-dimensional, stochastic simulation of biofilm growth and transport-related factors that affect structure.” Microbiology 149:2859-2871.
  7. D. J. Scott, B. M.T. da Costa, S. C. Espy, J. D. Keasling, and Katrina Cornish. 2003. “Activation and inhibition of rubber transferases by metal cofactors and pyrophosphate substrates.” Phytochemistry 64:123-134.
  8. M. M. Maharbiz, W.J. Holtz, S. Sharifzadeh, J. D. Keasling, R. T. Howe. 2003. “A microfabricated electrochemical oxygen generator for high-density cell culture arrays.” IEEE J. Microelectromech. Syst. 12:590-599.
  9. I. S. Aldor and J. D. Keasling. 2003. “Process design for microbial plastic factories: metabolic engineering of polyhydroxyalkanoates.” Curr. Opin. Biotechnol. 14:475-483.
  10. C. Khosla and J. D. Keasling. 2003. “Metabolic engineering for drug discovery and development.” Nature Rev. Drug Disc. 2:1019-1025.

2002

  1. C. D. Smolke and J. D. Keasling. 2002. “Effect of copy number and mRNA processing and stabilization on transcript and protein levels from an engineered dual-gene operon.” Biotechnol. Bioeng. 78:412-424.
  2. N. Renninger, K. D. McMahon, R. Knopp, H. Nitsche, D. S. Clark, and J. D. Keasling. 2002. “Uranyl precipitation by biomass from an enhanced biological phosphorus removal reactor.” Biodegradation 12:401-410.
  3. C. L. Wang, S. C. Ozuna, D. S. Clark, and J. D. Keasling. 2002. “A deep-sea hydrothermal vent isolate, Pseudomonas aeruginosa CW961, requires thiosulfate for Cd2+ tolerance and precipitation.” Biotechnol. Lett. 24:637-641.
  4. A. W. Walker and J. D. Keasling. 2002. “Metabolic engineering of Pseudomonas putida for the utilization of parathion as a carbon and energy source.” Biotechnol. Bioeng. 78:715-721.
  5. V. J. J. Martin, C. D. Smolke, and J. D. Keasling. 2002. “Redesigning cells for production of complex organic molecules.” ASM News 68:336-343.
  6. A. Magyarosy, R. D. Laidlaw, R. Kilaas, C. Echer, D. S. Clark, and J. D. Keasling. 2002. “Nickel accumulation and nickel oxalate precipitation by Aspergillus niger.” Appl. Microbiol. Biotechnol. 59:381-388.
  7. A. Magyarosy, J. Z. Ho, H. Rapoport, S. Dawson, J. Hancock, and J. D. Keasling. 2002. “Chlorxanthomycin, a fluorescent, chlorinated, pentacyclic pyrene from a Bacillus sp.” Appl. Environ. Microbiol. 68:4095-4101.
  8. I. S. Aldor, S.-W. Kim, K. L. Jones, and J. D. Keasling. 2002. “Metabolic engineering of a novel propionate-independent pathway for the production of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) in recombinant Salmonella enterica serovar Typhimurium.” Appl. Environ. Microbiol. 68:3848-3854.
  9. A. Khlebnikov, T. Skaug, and J. D. Keasling. 2002. “Modulation of gene expression from the arabinose-inducible araBAD promoter.” J. Ind. Microbiol. Biotechnol. 29:34-37.
  10. N. L. Goeden-Wood, V. P. Conticello, S. J. Muller, and J. D. Keasling. 2002. “Improved assembly of multimeric genes for the biosynthetic production of protein polymers.” Biomacromolecules 3:874-879.
  11. A. Khlebnikov and J. D. Keasling. 2002. “Effect of lacY expression on homogeneity of induction from the Ptac and Ptrc promoters by natural and synthetic inducers.” Biotechnol. Prog. 18:672-674.
  12. K. D. McMahon, D. Jenkins, and J. D. Keasling. 2002. “Polyphosphate kinase genes from activated sludge carrying out enhanced biological phosphorus removal.” Water Sci. Technol. 46:155-162.
  13. K. D. McMahon, M. A. Dojka, N. R. Pace, D. Jenkins, and J. D. Keasling. 2002. “Polyphosphate kinase from activated sludge performing enhanced biological phosphorus removal.” Appl. Environ. Microbiol. 68:4971-4978.
  14. C. D. Smolke and J. D. Keasling. 2002. “Effect of gene location, mRNA secondary structures, and RNase sites on expression of two genes in an engineered operon.” Biotechnol. Bioeng. 80:762-776.
  15. G.-Y. Wang and J. D. Keasling. 2002. “Amplification of HMG-CoA reductase production enhances carotenoid accumulation in Neurospora crassa.” Met. Eng. 4:193-201.

2001

  1. S.-W. Kim and J. D. Keasling. 2001. “Metabolic engineering of the nonmevalonate isopentenyl diphosphate synthesis pathway in Escherichia coli enhances lycopene production.” Biotechnol. Bioeng. 72:408-415.
  2. C. L. Wang, A. M. Lum, S. C. Ozuna, D. S. Clark, and J. D. Keasling. 2001. “Aerobic sulfide production and cadmium precipitation by Escherichia coli expressing the Treponema denticola cysteine desulfhydrase gene.” Appl. Microbiol. Biotechnol. 56:425-430.
  3. S. E. Cowan, D. Leipmann, and J. D. Keasling. 2001. “Development of engineering biofilms on poly-L-lysine patterned surfaces.” Biotechnol. Lett. 23:1235-1241.
  4. I. Aldor and J. D. Keasling. 2001. “Metabolic engineering of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) composition in recombinant Salmonella enterica serovar Typhimurium.” Biotechnol. Bioeng. 76:108-114.
  5. C. L. Wang, D. S. Clark, and J. D. Keasling. 2001. “Analysis of an engineered sulfate reduction pathway and cadmium precipitation on the cell surface.” Biotechnol. Bioeng. 75:285-291.
  6. C. D. Smolke, V. J. J. Martin, and J. D. Keasling. 2001. “Controlling the metabolic flux through the carotenoid pathway using directed mRNA processing and stabilization.” Met. Eng. 3:313-321.
  7. V. J. J. Martin, Y. Yoshikuni, and J. D. Keasling. 2001. “The in vivo synthesis of plant sesquiterpenes in Escherichia coli.” Biotechnol. Bioeng. 75:497-503.
  8. C. D. Smolke, A. Khlebnikov, and J. D. Keasling. 2001. “Effects of transcription induction homogeneity and transcript stability on expression of two genes in a constructed operon.” Appl. Microbiol. Biotechnol. 57:689-696.
  9. A. Khlebnikov, K. A. Datsenko, T. Skaug, B. L. Wanner, and J. D. Keasling. 2001. “Homogeneous expression of the PBAD promoter in Escherichia coli by constitutive expression of the low-affinity high-capacity AraE transporter.” Microbiology 147:3241-3247.
  10. E. S. Gilbert, A. Khlebnikov, S. E. Cowan, and J. D. Keasling. 2001. “Analysis of biofilm structure and gene expression using fluorescence dual labeling.” Biotechnol. Prog. 17:1180-1182.

2000

  1. S. E. Cowan, E. Gilbert, A. Khlebnikov, and J. D. Keasling. 2000. “Dual labeling with green fluorescent proteins for confocal microscopy.” Appl. Environ. Microbiol. 66:413-418.
  2. D. S. Reichmuth, J. L. Hittle, H. W. Blanch, and J. D. Keasling. 2000. “Biodesulfurization of dibenzothiophene in Escherichia coli is enhanced by expression of a Vibrio harveyi oxidoreductase gene.” Biotechnol. Bioeng. 67:72-79.
  3. J. D. Keasling, S. J. Van Dien, P. Trelstad, N. Renninger, and K. McMahon. 2000. “Application of polyphosphate metabolism to environmental and biotechnological problems.” Biochemistry (Moscow). 65:324-331.
  4. D. G. Bolesch and J. D. Keasling. 2000. “The effect of monovalent ions on polyphosphate binding to Escherichia coli exopolyphosphatase.” Biochem. Biophys. Res. Comm. 274:236-241.
  5. S.-W. Bang, D. S. Clark, and J. D. Keasling. 2000. “Engineering hydrogen sulfide production and cadmium removal by expression of the thiosulfate reductase gene (phsABC) from Salmonella enterica serovar Typhimurium in Escherichia coli.” Appl. Environ. Microbiol. 66:3939-3944.
  6. C. L. Wang, P. D. Maratukulam, A. M. Lum, D. S. Clark, and J. D. Keasling. 2000. “Metabolic engineering of an aerobic sulfate reduction pathway and its application to precipitation of cadmium on the cell surface.” Appl. Environ. Microbiol. 66:4497-4502.
  7. S. E. Cowan, E. Gilbert, D. Liepmann, and J. D. Keasling. 2000. “Commensal interactions in a dual-species biofilm exposed to mixed organic compounds.” Appl. Environ. Microbiol. 66:4481-4485.
  8. S.-W. Bang, D. S. Clark, and J. D. Keasling. 2000. “Cadmium, lead, and zinc removal by expression of the thiosulfate reductase gene from Salmonella typhimurium in Escherichia coli.” Biotechnol. Lett. 22:1331-1335.
  9. D. G. Bolesch and J. D. Keasling. 2000. “Polyphosphate binding and chain length recognition of Escherichia coli exopolyphosphatase.” J. Biol. Chem. 275:33814-33819.
  10. A. Khlebnikov, O. Risa, T. Skaug, T. A. Carrier, and J. D. Keasling. 2000. “Regulatable arabinose-inducible gene expression system with consistent control in all cells of a culture.” J. Bacteriol. 182:7029-7034.
  11. C. D. Smolke, T. A. Carrier, and J. D. Keasling. 2000. “Coordinated, differential expression of two genes through directed mRNA cleavage and stabilization by secondary structures.” Appl. Environ. Microbiol. 66:5399-5405.
  12. K. L. Jones, S.-W. Kim, and J. D. Keasling. 2000. “Low-copy plasmids can perform as well as or better than high-copy plasmids for metabolic engineering of bacteria.” Met. Eng. 2:328-338.

1999

  1. R. Brent Nielsen and J. D. Keasling. 1999. “Reductive dechlorination of chlorinated ethene DNAPLs by a culture enriched from contaminated groundwater.” Biotechnol. Bioeng. 62:160-165.
  2. T. A. Carrier and J. D. Keasling. 1999. “A library of synthetic 5' secondary structures to manipulate mRNA stability in Escherichia coli.” Biotechnol. Prog. 15:58-64.
  3. E. Gilbert, A. Khlebnikov, W. Meyer-Ilse, and J. D. Keasling. 1999. “Use of soft X-ray microscopy for analysis of early-stage biofilm formation.” Wat. Sci. Tech. 39(7):269-272.
  4. S. J. Van Dien and J. D. Keasling. 1999. “Effect of polyphosphate metabolism on the Escherichia coli phosphate-starvation response.” Biotechnol. Prog. 15(4):587-593.
  5. S. E. Cowan, J. Black, J. D. Keasling, and R. M. White. 1999. “Ultrasonic flexural-plate-wave sensor for detecting the concentration of settling E. coli W3110 cells.” Analytical Chemistry. 71(16):3622-3625.
  6. P. L. Trelstad, P. Purdhani, W. Geibdorfer, W. Hillen, and J. D. Keasling. 1999. “Polyphosphate kinase of Acinetobacter sp. Strain ADP1: purification and characterization of the enzyme and its role during changes in extracellular phosphate.” Appl. Environ. Microbiol. 65(9):3780-3786.
  7. J. D. Keasling. 1999. “Gene-expression tools for the metabolic engineering of bacteria.” Trends in Biotechnology 17:452-460.
  8. T. A. Carrier and J. D. Keasling. 1999. “Investigating autocatalytic gene expression systems through mechanistic modeling.” J. Theor. Biol. 201:25-36.

1998

  1. J. D. Keasling, S. J. Van Dien, and J. Pramanik. 1998. “Engineering polyphosphate metabolism in Escherichia coli: implications for bioremediation of inorganic contaminants.” Biotechnol. Bioeng. 58:231-239.
  2. S. J. Van Dien and J. D. Keasling. 1998. “A dynamic model of the Escherichia coli phosphate-starvation response.” J. Theor. Biol. 190:37-49.
  3. J. D. Keasling and S.-W. Bang. 1998. “Recombinant DNA techniques for bioremediation and environmentally-friendly synthesis.” Current Biology 9:135-140.
  4. S. Cooper and J. D. Keasling. 1998. “Cycle-specific replication of chromosomal and F-plasmid origins.” FEMS Microbiol. Lett. 163:217-222.
  5. K. L. Jones and J. D. Keasling. 1998. “Construction and characterization of F plasmid-based expression vectors.” Biotechnol. Bioeng. 59:659-665.
  6. T. A. Carrier, K. L. Jones, and J. D. Keasling. 1998. “mRNA stability and plasmid copy number effects on gene expression from an inducible promoter system.” Biotechnol. Bioeng. 59:666-672.
  7. S. J. Van Dien and J. D. Keasling. 1998. “Optimization of polyphosphate degradation and phosphate secretion using hybrid metabolic pathways and engineered host strains.” Biotechnol. Bioeng. 59:754-761.
  8. J. Pramanik, P. L. Trelstad, and J. D. Keasling. 1998. “A flux-based stoichiometric model of enhanced biological phosphorus removal metabolism.” Wat. Sci. Tech. 37:609-613.
  9. J. Pramanik and J. D. Keasling. 1998. “Effect of carbon source and growth rate on biomass composition and metabolic flux predictions of a stoichiometric model.” Biotechnol. Bioeng. 60:230-238.
  10. S. J. Van Dien and J. D. Keasling. 1998. “Control of polyphosphate metabolism in genetically-engineered Escherichia coli.” Enzyme Microb. Technol. 24:21-25.
  11. J. Pramanik, P. L. Trelstad, A. J. Schuler, D. Jenkins, and J. D. Keasling. 1998. “Development and validation of a flux-based stoichiometric model for enhanced biological phosphorus removal metabolism.” Water Research 33:462-476.

1997

  1. S. J. Van Dien, S. Keyhani, C. Yang, and J. D. Keasling. 1997. “Manipulation of independent synthesis and degradation of polyphosphate in Escherichia coli for investigation of phosphate secretion from the cell.” Appl. Environ. Microbiol. 63:1689-1695.
  2. J. Elmen, W. Pan, S. Y. Leung, A. Magyarosy, and J. D. Keasling. 1997. “Kinetics of toluene degradation by a nitrate-reducing bacterium isolated from a groundwater aquifer.” Biotechnol. Bioeng. 55:82-90.
  3. T. A. Carrier and J. D. Keasling. 1997. “Engineering mRNA stability in E. coli by the addition of synthetic hairpins using a 5’ cassette system.” Biotechnol. Bioeng. 55:577-580.
  4. C. L. Wang, P. C. Michels, S. Dawson, S. Kitisakkul, J. A. Baross, J. D. Keasling, and D. S. Clark. 1997. “Cadmium removal by a new strain of Pseudomonas aeruginosa in aerobic culture.” Appl. Environ. Microbiol. 63:4075-4078.
  5. J. Pramanik and J. D. Keasling. 1997. “A stoichiometric model of Escherichia coli metabolism: incorporation of growth-rate dependent biomass composition and mechanistic energy requirements.” Biotechnol. Bioeng. 56:398-421.
  6. T. A. Carrier and J. D. Keasling. 1997. “Controlling messenger RNA stability in bacteria: strategies for engineering gene expression.” Biotechnol. Prog. 13:699-708.
  7. T. A. Carrier and J. D. Keasling. 1997. “Mechanistic modelling of mRNA decay.” J. Theor. Biol. 189:195-209.

1996

  1. J. D. Keasling and G. A. Hupf. 1996. “Genetic manipulation of polyphosphate metabolism affects cadmium tolerance in Escherichia coli.” Appl. Environ. Microbiol. 62:743-746.
  2. S. T. Sharfstein, S. J. Van Dien, and J. D. Keasling. 1996. “Modulation of the phosphate-starvation response in Escherichia coli by genetic manipulation of the polyphosphate pathways.” Biotechnol. Bioeng. 51:434-438.
  3. N. Shapiro and J. D. Keasling. 1996. “The recA gene and cadmium toxicity in Escherichia coli K-12.” Microbios 86:23-26.
  4. H. Kuo and J. D. Keasling. 1996. “A Monte Carlo simulation of plasmid replication during the bacterial division cycle.” Biotechnol. Bioeng. 52:633-647.
  5. S. Keyhani, J. L. Lopez, D. S. Clark, and J. D. Keasling. 1996. “Intracellular polyphosphate content and cadmium tolerance in Anacystis nidulans R2.” Microbios 88:105-114.
  6. P. Wong, S. Gladney, and J. D. Keasling. 1996. “A mathematical model of the lac operon: inducer exclusion, catabolite repression, and diauxic growth on glucose and lactose.” Biotechnol. Prog. 13:132-143.

1995

  1. J. D. Keasling, H. Kuo, and G. Vahanian. 1995. “A Monte Carlo simulation of the Escherichia coli cell cycle.” J. Theor. Biol. 176:411-430.

1994

  1. J. D. Keasling and S. Cooper. 1994. “Analysis of plasmid replication during the bacterial division cycle.” Methods in Molecular Genetics 3:380-388.
  2. T. R. Hupp, J. D Keasling, S. Cooper, and J. M. Kaguni. 1994. “Synthesis of DnaK protein during the division cycle of Escherichia coli.” Res. Microbiol. 145:99-109.

1993

  1. J. D. Keasling, L. Bertsch, and A. Kornberg. 1993. “Guanosine pentaphosphate phosphohydrolase of Escherichia coli is a long-chain polyphosphatase.” Proc. Natl. Acad. Sci. USA 90:7029-7033.
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