EDUCATION:

Ph.D.   Chemistry, The Scripps Research Institute

B.S.     Chemistry and Biological Chemistry, Nanyang Technological University

CONTACT INFORMATION:

Email  luoxz at lbl dot gov
Phone  N/A
Office  4510F
Bench  4550
Address
5885 Hollis St., 4th floor
Emeryville, CA 94608
Website  N/A

CURRENT RESEARCH:

Engineering polyketide synthases for the production of biofuels and natural products with therapeutic applications.

PUBLICATIONS:

Wang, R.E.; Wang, Y.; Zhang, Y.; Gabrelow, C.; Zhang, Y.; Chi, V.; Fu, Q.; Luo, X.; Wang, D.; Joseph, S.; Johnson, K.; Chatterjee, A.K.; Wright, T.M.; Nguyen-Tran, V.T.B.; Teijaro, J.; Theofilopoulos, A.N.; Schultz, P.G.; Wang, F. “Rational design of a Kv1. 3 channel-blocking antibody as a selective immunosuppressant”, Proc. Nat. Acad. Sci. 2016

·        Luo, X.*; Wang, T.-S.A*; Zhang, Y.; Wang, F.; Schultz, P. G. “Stabilizing Protein Motifs with a Genetically Encoded Metal-Ion Chelator”, Cell. Chem. Biol., 2016, 23, 1098. *Authors contributed equally

·        Xuan, W.; Li, J.; Luo, X.; Schultz, P.G. “Genetic Incorporation of a Reactive Isothiocyanate Group into Proteins”, Angew. Chem. Int. Ed. 2016, 128, 10219.

·        Liu, T.; Wang, Y.; Luo, X.; Li, J.; Reed, S.A.; Xiao, H.; Young, T.S.; Schultz, P.G. “Enhancing protein stability with extended disulfide bonds” Proc. Nat. Acad. Sci. 2016, 113, 5910.

·        Cao, Y.; Rodgers, D.T.; Du, J.; Ahmad, I.; Hampton, E.N.; Ma, J.S.Y; Mazagova, M.; Choi, S.-H.; Yun, H.Y.; Xiao, H.; Yang, P.; Luo, X.; Lim, R.K.V.; Pugh, H.M.; Wang, F.; Kazane, S.A.; Wright, T.M.; Kim, C.H.; Schultz, P.G.; Young, T.S. “Design of Switchable Chimeric Antigen Receptor T Cells Targeting Breast Cancer”, Angew. Chem. Int. Ed. 2016, 128, 7646.

·        Yang, P.-Y.; Zou, H.; Chao, E.; Sherwood, L.; Nunez, V.; Keeney, M.; Ghartey-Tagoe, E.; Ding, Z.; Quirino, H.; Luo, X.; Welzel, G.; Chen, G.; Singh, P.; Woods, A.K.; Schultz, P.G.; Shen, W. “Engineering a long-acting, potent GLP-1 analog for microstructure-based transdermal delivery”, Proc. Nat. Acad. Sci. 2016, 113, 4140.

·        Luo, X.; Zambaldo, C.; Liu, T.; Zhang, Y.; Xuan, W.; Wang, C.; Reed, S.A.; Yang, P.Y.; Wang, R.E.; Javahishvili, T.; Schultz, P. G.; Young, T.S. “Recombinant Thiopeptides with Noncanonical Amino Acids”, Proc. Nat. Acad. Sci. 2016, 113, 3615.

·        Luo, X.*; Liu, T.*; Wang, Y.; Jia, H.; Zhang, Y.; Caballero, D.; Du, J.; Wang, R. E.; Wang, D.; Schultz, P. G.; Wang, F. “An Epitope-Specific Respiratory Syncytial Virus Vaccine based on an Antibody Scaffold”, Angew. Chem. Int. Ed. 2015, 54, 1. *Authors contributed equally

·        Wang, F., Schultz, P.G., Luo, X.; Liu, T. “Antigenic Fusion Proteins and Methods of Vaccination”, U.S. Patent pending, 2015

·        Harbut, M. B.; Vilchèze, C.; Luo, X.; Hensler, M. E.; Guo, H.; Yang, B.; Chatterjee, A. K.; Nizet, V.; Jacobs, W. R.; Schultz, P. G. “Auranofin exerts broad-spectrum bactericidal activities by targeting thiol-redox homeostasis”, Proc. Nat. Acad. Sci. 2015, 112, 4453.

·        Liu, T.; Du, J.; Luo, X.; Schultz, P. G.; Wang, F. “Homogeneously modified immunoglobulin domains for therapeutic application”, Curr. Opin. Chem. Biol. 2015, 28, 66.

·        Liu, T.; Fu, G.; Luo, X.; Liu, Y.; Wang, Y.; Wang, R. E.; Schultz, P. G.; Wang, F. “Rational Design of Antibody Protease Inhibitors”, J. Am. Chem. Soc. 2015, 137, 4042.

·        Wang, R. E.; Liu, T.; Wang, Y.; Cao, Y.; Du, J.; Luo, X.; Deshmukh, V.; Kim, C. H.; Lawson, B. R.; Tremblay, M. S.; Young, T.S.; Kazane, S.A.; Wang, F.; Schultz, P.G. “An Immunosuppressive Antibody–Drug Conjugate”, J. Am. Chem. Soc. 2015, 137, 3229.

·        Liu, T.; Zhang, Y.; Liu, Y.; Wang, Y.; Jia, H.; Kang, M.; Luo, X.; Caballero, D.; Gonzalez, J.; Sherwood, L.; Nunez, V.; Wang, D.; Woods, A.; Schultz, P.G.; Wang, F. “Functional human antibody CDR fusions as long-acting therapeutic endocrine agonists”, Proc. Nat. Acad. Sci. 2015, 112, 1356.

·        Ma, J.; Ng, S.; Yong, Y.; Luo, X.; Wang, X.; Liu, X.-W. “Recyclable sulfonated amorphous carbon catalyzed Friedel–Crafts alkylation of indoles with a,b-unsaturated carbonyl compounds in water”,Chem. Asian J. 2010, 5, 778.