CharlesProfilePhoto2016

EDUCATION:

BA Biochemistry and Molecular Biology, Whitman College, 2005

PhD Molecular and Cellular Biology, UC Berkeley, 2012

CONTACT INFORMATION:

Email cmdenby@lbl.gov
Phone 206-799-2668
Office 4510-D
Bench 4550-10
Address
5885 Hollis St., 4th floor
Emeryville, CA 94608

Current Research

I am engineering microbes to produce chemicals for more sustainable production processes. I have focused on metabolic engineering of S. cerevisiae for production of natural products otherwise produced in plants. I am generally interested in microbial production of natural products, as well as using the flexibility of microbial biosynthesis for production of novel compounds.

Publications

  • Denby, Charles M.*, Sarah Rodriguez*, Van T. Vu, Edward E. K. Baidoo, George Wang, and Jay D. Keasling. 2016. “ATP citrate lyase mediated cytosolic acetyl-CoA biosynthesis increases mevalonate production in Saccharomyces cerevisiae” Microbial Cell Factories 15 (1): 48.

  • Rodriguez, Sarah, James Kirby, Charles M. Denby, and Jay D. Keasling. 2014. “Production and Quantification of Sesquiterpenes in Saccharomyces Cerevisiae, Including Extraction, Detection and Quantification of Terpene Products and Key Related Metabolites.” Nature Protocols 9 (8): 1980–96.

  • Denby, Charles M., Joo Hyun Im, Richard C. Yu, C. Gustavo Pesce, and Rachel B. Brem. 2012. “Negative Feedback Confers Mutational Robustness in Yeast Transcription Factor Regulation.” Proceedings of the National Academy of Sciences of the United States of America 109 (10): 3874–78.