Diplom Engineer Mannheim University of Applied Sciences, Biotechnology Department, Germany

Doctoral dissertation Heidelberg University, Medical Faculty, Germany with University of California San Diego, Scripps Institution of Oceanography, USA


Email ……
Phone ….. 619-309-8317
Office …… 4110-D
Bench ….. 4550-24
5885 Hollis St., 4th floor
Emeryville, CA 94608

Current Research

Probing host-specificity of bacterial type I polyketide synthases through ribosomal profiling and in vitro enzyme characterization

Engineering PKS precursor supply in S. cerevisiae for production of value-added chemicals


  • Ebrahim A, Brunk E, Tan J, O’Brien EJ,  Kim D, Szubin R, Lerman JA, Lechner A, Sastry A, Bordbar A, Feist AM, Palsson BO. Multi-omic data integration enables discovery of hidden biological regularities. Submitted 2016
  • Lechner A, Brunk E, Keasling J. The Need for Integrated Approaches in Metabolic Engineering. Submitted 2016
  • Latif H, Szubin R, Tan J, Brunk E, Lechner A, Zengler K, Palsson BO. A streamlined ribosome profiling protocol for the characterization of microorganisms. Biotechniques. 2015 Jun 1;58(6):329-32.
  • Duncan KR*, Crüsemann M*, Lechner A*, Sarkar A, Li J, Ziemert N, Wang M, Bandeira N, Moore BS, Dorrestein PC, Jensen PR. Molecular networking and pattern-based genome mining improves discovery of biosynthetic gene clusters and their products from Salinispora species. Chem Biol. 2015 Apr 23;22(4):460-71. *Co-first author
  • Ziemert N, Lechner A, Wietz M, Millán-Aguiñaga N, Chavarria KL, Jensen PR. Diversity and evolution of secondary metabolism in the marine actinomycete genus Salinispora. Proc Natl Acad Sci U S A. [2014] 25, 111 (12)
  • Horsman G, Lechner A, Moore BS, Ohnishi Y, Shen BA Predictive Model for Epoxide Hydrolase-generated Stereochemistry in the Biosynthesis of 9-Membered Enediyne Antitumor Antibiotics Biochemistry.[2013] 31, 5217–24
  • Lechner A, Wilson M, Yoon JY, Moore BS. Designed biosynthesis of unnatural 36-methyl-FK506 by polyketide precursor pathway engineering. ACS Synth Biol. [2013] 7, 379-83
  • Lechner A, Eustaquio AS, Gulder TAM, Hafner M, Moore BS. Selective overproduction of the proteasome inhibitor salinosporamide A via precursor pathway regulation. Chemistry & biology [2011] 18, 1527–36
  • Kale JK, McGlinchey RP, Lechner A, Moore BS. Bacterial self-resistance to the natural proteasome inhibitor salinosporamide A. ACS Chem Biol [2011] 6, 1257–64
  • Eustaquio AS, Nam, SJ, Penn K, Lechner A, Wilson MC, Fenical W, Jensen PR, Moore BS. The discovery of salinosporamide K from the marine bacterium “Salinispora pacifica” by genome mining gives insight into pathway evolution. Chembiochem [2011] 12, 61–64
  • Eustaquio AS, McGlinchey RP, Liu Y, Hazzard C, Beer LL, Florova G, Alhamadsheh MM, Lechner A, Kale AJ, Kobayashi Y, Reynolds KA, Moore BS. Biosynthesis of the salinosporamide A polyketide synthase substrate chloroethylmalonyl-coenzyme A from S-adenosyl-L-methionine. Proc Natl Acad Sci U S A [2009] 106, 12295–300


09/2008 – 09/2011
PhD scholarship from University of Heidelberg, Medical Faculty in Mannheim 

09/2007 – 11/2007
DAAD diploma thesis scholarship 

03/2006 – 08/2006
InterStip student scholarship