EDUCATION:

Diplom Engineer Mannheim University of Applied Sciences, Biotechnology Department, Germany

Doctoral dissertation Heidelberg University, Medical Faculty, Germany with University of California San Diego, Scripps Institution of Oceanography, USA

CONTACT INFORMATION:

Email …… alechner@lbl.gov
Phone ….. 619-309-8317
Office …… 4110-D
Bench ….. 4550-24
Address
5885 Hollis St., 4th floor
Emeryville, CA 94608
LinkedIn: www.linkedin.com/in/annalechner
 

Current Research

Probing host-specificity of bacterial type I polyketide synthases through ribosomal profiling and in vitro enzyme characterization

Engineering PKS precursor supply in S. cerevisiae for production of value-added chemicals

Publications

  • Ebrahim A, Brunk E, Tan J, O’Brien EJ,  Kim D, Szubin R, Lerman JA, Lechner A, Sastry A, Bordbar A, Feist AM, Palsson BO. Multi-omic data integration enables discovery of hidden biological regularities. Submitted 2016
  • Lechner A, Brunk E, Keasling J. The Need for Integrated Approaches in Metabolic Engineering. Submitted 2016
  • Latif H, Szubin R, Tan J, Brunk E, Lechner A, Zengler K, Palsson BO. A streamlined ribosome profiling protocol for the characterization of microorganisms. Biotechniques. 2015 Jun 1;58(6):329-32.
  • Duncan KR*, Crüsemann M*, Lechner A*, Sarkar A, Li J, Ziemert N, Wang M, Bandeira N, Moore BS, Dorrestein PC, Jensen PR. Molecular networking and pattern-based genome mining improves discovery of biosynthetic gene clusters and their products from Salinispora species. Chem Biol. 2015 Apr 23;22(4):460-71. *Co-first author
  • Ziemert N, Lechner A, Wietz M, Millán-Aguiñaga N, Chavarria KL, Jensen PR. Diversity and evolution of secondary metabolism in the marine actinomycete genus Salinispora. Proc Natl Acad Sci U S A. [2014] 25, 111 (12)
  • Horsman G, Lechner A, Moore BS, Ohnishi Y, Shen BA Predictive Model for Epoxide Hydrolase-generated Stereochemistry in the Biosynthesis of 9-Membered Enediyne Antitumor Antibiotics Biochemistry.[2013] 31, 5217–24
  • Lechner A, Wilson M, Yoon JY, Moore BS. Designed biosynthesis of unnatural 36-methyl-FK506 by polyketide precursor pathway engineering. ACS Synth Biol. [2013] 7, 379-83
  • Lechner A, Eustaquio AS, Gulder TAM, Hafner M, Moore BS. Selective overproduction of the proteasome inhibitor salinosporamide A via precursor pathway regulation. Chemistry & biology [2011] 18, 1527–36
  • Kale JK, McGlinchey RP, Lechner A, Moore BS. Bacterial self-resistance to the natural proteasome inhibitor salinosporamide A. ACS Chem Biol [2011] 6, 1257–64
  • Eustaquio AS, Nam, SJ, Penn K, Lechner A, Wilson MC, Fenical W, Jensen PR, Moore BS. The discovery of salinosporamide K from the marine bacterium “Salinispora pacifica” by genome mining gives insight into pathway evolution. Chembiochem [2011] 12, 61–64
  • Eustaquio AS, McGlinchey RP, Liu Y, Hazzard C, Beer LL, Florova G, Alhamadsheh MM, Lechner A, Kale AJ, Kobayashi Y, Reynolds KA, Moore BS. Biosynthesis of the salinosporamide A polyketide synthase substrate chloroethylmalonyl-coenzyme A from S-adenosyl-L-methionine. Proc Natl Acad Sci U S A [2009] 106, 12295–300

Awards

09/2008 – 09/2011
PhD scholarship from University of Heidelberg, Medical Faculty in Mannheim 

09/2007 – 11/2007
DAAD diploma thesis scholarship 

03/2006 – 08/2006
InterStip student scholarship